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Glucosamine is found naturally in the body. It stimulates the formation and repair of articular cartilage. Over-the-counter supplements come from animal sources. Chondroitin sulfate is another natural substance found in the body. It prevents other body enzymes from degrading the building blocks of joint cartilage. The type sold in health-food stores and pharmacies is derived from animal products.

Glucosamine is a building block of connective tissue, while chondroitin helps cartilage retain water so it stays flexible. Together they soothe sore joints. A study in the New England Journal of Medicine reports that 79 percent of men who took 1,500 mg glucosamine and 1,200 mg chondroitin daily felt a significant reduction in chronic knee pain. Glucosamine-chondroitin supplements take longer to work than NSAIDs (non-steroidal pain killers like aspirin and ibuprofen), but have fewer side effects and last longer. Russian researchers also found that chondroitin reduces back pain.

People who use these nutritional supplements hope that they will relieve the pain of osteoarthritis, and perhaps even repair or restore the joint cartilage. Recent evidence seems to support the first claim. Both glucosamine and chondroitin sulfate have been used in Europe for several years, with few reported side effects. Both supplements also have some anti-inflammatory effects that may account for the pain relief.

But there is no proof that either substance, taken singly or in combination, will actually slow the degenerative process or restore cartilage in arthritic joints. All studies done to date have been short and focused on pain relief. A long-term study is just beginning, sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Center for Complementary and Alternative Medicine.

Dietary supplements like glucosamine and chondroitin sulfate are not tested or analyzed by the Food and Drug Administration before they are sold to consumers. That means consumers can't be sure they're getting what they pay for when they purchase bottles labeled "Glucosamine/Chondroitin." In fact, a recent study by ConsumerLab.com showed that almost half of the glucosamine/ chondroitin supplements tested did not contain the labeled amounts of ingredients.

Conditions

  • Knee pain
  • Back pain

Recommendations

  • Try 2 to 3 capsules of Cosamin DS daily

Interactions & Side Effects

  • Shellfish allergy. Reactions are rare but if you’re allergic to shellfish (glucosamine is made from shellfish shells), check with your healthcare provider before you take the supplement, or try a vegetarian version.
  • Insulin. May reduce effectiveness

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Disclaimer: This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regime, it is advisible to seek the advice of a licensed healthcare professional.

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